Complete nucleotide sequences of Marburg virus genes 5 and 6 encoding VP30 and VP24 proteins.
Biochem Mol Biol Int
; 35(3): 605-13, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7773195
ABSTRACT
Nucleotide sequences of the genes 5 and 6 of the Marburg virus, Popp strain, were determined. ORFs encoding polypeptides VP30 (281 a.a., MW 32,640) and VP24 (253 a.a., MW 28,621) were found. The putative transcription start and stop signals for viral RNA-dependent RNA polymerase were revealed for both genes. Overlapping of genes 5 and 6 was shown. The deduced amino acid sequences of VP30 and VP24 proteins displayed significant homology with the analogous proteins of another filovirus, the Ebola virus (33% and 37%, respectively). The VP24 appeared to have a hydrophobic amino acid composition; content of hydrophobic amino acids was 40.7%. Model of VP24 location in the virion was suggested.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Genes Virais
/
Marburgvirus
Idioma:
En
Revista:
Biochem Mol Biol Int
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Federação Russa