[Reproductive and developmental toxicity studies of lactitol (NS-4) (3)--Teratogenicity study in rabbits by oral administration].
J Toxicol Sci
; 19 Suppl 3: 463-70, 1994 Nov.
Article
em Ja
| MEDLINE
| ID: mdl-7837299
ABSTRACT
Lactitol, a hepatic encephalopathy drug, was administered by oral gavage to pregnant New Zealand White rabbits during organogenesis from day 6 to day 18 of gestation inclusive, at dosages of 0, 0.25, 0.75 or 4.5 g/kg/day. On day 29 of gestation, females were killed to allow examination of their uterine contents. There was a slight reduction in food intake and faecal output among females receiving 4.5 g/kg. One female receiving 4.5 g/kg aborted following a prolonged period of weight loss. No adverse effects on litter parameters were recorded that could be attributed to treatment. Foetal morphogenesis was unaffected by treatment with lactitol. The results show that no-effect dose levels of lactitol are 0.75 g/kg in mother rabbits for general toxicity and for reproductive functions, and 4.5 g/kg for their fetuses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Álcoois Açúcares
/
Anormalidades Induzidas por Medicamentos
/
Desenvolvimento Embrionário e Fetal
Limite:
Animals
/
Pregnancy
Idioma:
Ja
Revista:
J Toxicol Sci
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido