Minisatellite mutation rate variation associated with a flanking DNA sequence polymorphism.
Nat Genet
; 8(2): 162-70, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7842015
ABSTRACT
Human minisatellite mutation in the male germline frequently involves complex interallelic gene conversion events restricted to one end of the tandem repeat array. Some alleles at minisatellite MS32 show reduced variability in human populations and are associated with a G to C transversion upstream of the array. Analysis of single sperm demonstrated a frequently profound reduction in mutation rate at alleles carrying the C variant. This mutation suppression acts in cis, but does not affect the ability of an allele to act as sequence donor during gene conversion. This mutation rate polymorphism provides strong evidence for elements near the minisatellite that regulate tandem repeat instability.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
DNA Satélite
/
Mutação
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
/
Male
País/Região como assunto:
Africa
/
Asia
Idioma:
En
Revista:
Nat Genet
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido