[Effects of sodium fluoride on the activity of Ca2+Mg(2+)-ATPase in synaptic membrane in rat brain].
Zhonghua Yu Fang Yi Xue Za Zhi
; 28(5): 264-6, 1994 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-7842887
ABSTRACT
Effects of sodium fluoride on Ca2+Mg(2+)-ATPase activity of synaptic membrane in rat brain were studied with in vitro or in vivo methods. Concentrations of sodium fluoride of 0.3, 1.6, 8.0, 20.0 and 40.0 mmol/L can significantly inhibit the activity of the enzyme with proportions of 6.6%, 18.0%, 41.0%, 55.5% and 63.1%, respectively, and with a half inhibitory concentration of 14.8 mmol/L reflecting an obvious dose-effect and time effect relationship. Analysis of enzyme substrate kinetics showed the effect that sodium fluoride had was a non competitive inhibition. Activity of Ca2+Mg(2+)-ATPase on synaptic membrane in female rat brain showed a decreasing tendency after feeding with water fluorinated with 5, 15 and 50 mg/L of fluoride during their gestation and lactation for 50 days, and that in their newborn offsprings with 5 and 50 mg/L of fluoride was inhibited by 11.3 and 32.1%, respectively.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fluoreto de Sódio
/
Membranas Sinápticas
/
Encéfalo
/
ATPase de Ca(2/) e Mg(2/)
Limite:
Animals
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Yu Fang Yi Xue Za Zhi
Ano de publicação:
1994
Tipo de documento:
Article