Binding strength between cell adhesion proteoglycans measured by atomic force microscopy.
Science
; 267(5201): 1173-5, 1995 Feb 24.
Article
em En
| MEDLINE
| ID: mdl-7855599
ABSTRACT
Measurement of binding forces intrinsic to adhesion molecules is necessary to assess their contribution to the maintenance of the anatomical integrity of multicellular organisms. Atomic force microscopy was used to measure the binding strength between cell adhesion proteoglycans from a marine sponge. Under physiological conditions, the adhesive force between two cell adhesion molecules was found to be up to 400 piconewtons. Thus a single pair of molecules could hold the weight of 1600 cells. High intermolecular binding forces are likely to form the basis for the integrity of the multicellular sponge organism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Proteoglicanas
/
Proteínas
/
Moléculas de Adesão Celular
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Suíça