A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients.
J Trauma
; 38(2): 233-6, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7869442
ABSTRACT
OBJECTIVE:
To evaluate the effects of recombinant human erythropoietin (r-HuEPO) in attempting to prevent anemia in acutely burned patients.DESIGN:
Prospective double-blind randomized study of 40 patients.METHODS:
Patients with burns from 25% to 65% total body surface were enrolled. r-HuEPO or a placebo was begun within 72 hours of admission. Cell blood count, reticulocyte counts, transfusion requirements, and blood loss were measured. Comparison was carried out by the unpaired t test. MAINRESULTS:
There was no statistically significant difference in hemoglobin, hematocrit, reticulocyte count, ferritin, serum iron, total iron blinding capacity, or transfusion requirements. In patients with burns from 25% to 35%, the reticulocyte counts were statistically significantly higher.CONCLUSION:
In our work the administration of r-HuEPO in acutely burned patients did not prevent the development of postburn anemia or decrease transfusion requirements. Increased erythropoiesis in smaller burns (25% to 35%) was observed and may indicate a reason for further study.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queimaduras
/
Eritropoetina
/
Anemia
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Trauma
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Geórgia