Transitions of latency time and oscillation phase on parameter surfaces from models of intracellular calcium ion dynamics.
Biosystems
; 33(3): 177-92, 1994.
Article
em En
| MEDLINE
| ID: mdl-7888609
ABSTRACT
The dynamics of two classical elementary compartmental models stimulating intracellular calcium ion oscillatory behavior are examined in terms of parameter surfaces. It has been found that, along certain lines of instability on surfaces defined by model parameters, the highly non-linear nature of these models produces sharp transitions in the latency time which determines the phase of oscillations once they commence. This sensitivity to initial conditions in deterministic models, along with the stochastic variance inevitably present in actual biological systems, illustrates how two seemingly identical cells activated by identical synchronous stimulation can exhibit oscillatory responses which are out of phase with respect to each other.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Biosystems
Ano de publicação:
1994
Tipo de documento:
Article