Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.
Infect Immun
; 62(6): 2614-8, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-7910596
ABSTRACT
Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leishmania braziliensis
/
Linfócitos T CD4-Positivos
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Subpopulações de Linfócitos T
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Leishmaniose Cutânea
/
Antígenos CD8
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Animals
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Brasil