A clinical and epidemiological study of human leukocyte antigen-DPB alleles in Hodgkin's disease.
Cancer Res
; 54(19): 5101-5, 1994 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-7923125
ABSTRACT
An international study to investigate the role of human leukocyte antigen (HLA)-DPB alleles in Hodgkin's disease was conducted with 17 participating centers in 12 countries. A total of 741 patients and 686 controls were typed using polymerase chain reaction amplification of HLA-DPB alleles and subsequent sequence specific oligonucleotide hybridization. The frequency of HLA-DPB1*0301 was found to be significantly increased in white patients, compared with ethnically matched controls. In this population group, the DPB1*0301 allele is associated with a relative risk of 1.95 (P < 0.01). There was also a significant reduction in the frequency of HLA-DPB1*0401 in patients from Japan and Taiwan (relative risk, 0.15; P < 0.01). Clinical analysis from data on 551 patients demonstrated a significantly inferior remission duration in patients with HLA-DPB1*0901, overall (P < 0.05), and in the Japanese and Taiwanese populations (P = 0.02), where this allele is most prevalent. This analysis suggests an epidemiological as well as a possible prognostic association between HLA-DPB alleles and Hodgkin's disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Hodgkin
/
Antígenos HLA-DP
/
Alelos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido