Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD.
J Nucl Med
; 35(12): 1896-901, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7989966
ABSTRACT
UNLABELLED The aim of this study was to evaluate the use of 99mTc-ethyl cysteinate dimer (ECD), also known as 99mTc-bicisate, in the presurgical evaluation of patients suffering from medically intractable epilepsy. METHODS:
Twenty-three brain SPECT studies (8 ictally and 15 interictally) were performed on 16 patients with a high-resolution annular SPECT system (CERASPECT). For the ictal studies, the tracer was injected in the very early phase of the seizure. The delay between seizure onset and 99mTc-ECD injection was 2-20 sec.RESULTS:
Interictally, all patients showed circumscribed hypoperfusions. In four patients, the SPECT lesion represented only structural defects. Circumscribed increased tracer uptake was observed in all ictal studies. For all patients with temporal lobe epilepsy without significant mass lesion, in whom an interictal and ictal 99mTc-ECD-SPECT study could be obtained, the asymmetry index was 0.88 +/- 0.03 for the interictal and 1.23 +/- 0.08 for the ictal studies.CONCLUSION:
The data suggest that 99mTc-ECD is an effective marker of cerebral perfusion imaging in epilepsy. In comparison to other tracers, it has a high in vitro stability and is therefore particularly useful for ictal studies in the very early phase after seizure onset.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Compostos de Organotecnécio
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Cisteína
/
Epilepsia
Limite:
Adolescent
/
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha