Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.
Science
; 262(5141): 1892-5, 1993 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-8018146
ABSTRACT
Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Leb antigen or antibodies to the Leb antigen inhibited bacterial binding. Gastric tissue lacking Leb expression did not bind H. pylori. Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Helicobacter pylori
/
Mucosa Gástrica
/
Antígenos do Grupo Sanguíneo de Lewis
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1993
Tipo de documento:
Article