Maternal/fetal interactions: the role of the MHC class I molecule HLA-G.
Crit Rev Immunol
; 13(3-4): 207-24, 1993.
Article
em En
| MEDLINE
| ID: mdl-8110376
ABSTRACT
The unique pattern of class I major histocompatibility complex (MHC) antigen expression seen at the human maternal/fetal interface is thought to be vital for fetal well-being. The lack of polymorphic class I and II MHC antigens on trophoblasts, the only fetal tissue in direct contact with the mother, is likely to be at least a part of the explanation of fetal evasion of allograft rejection. The recent observation that the HLA-G-encoded class I MHC molecule is present on certain subpopulations of cytotrophoblasts suggests that this nonpolymorphic molecule may have a role in the maternal/fetal immune response. Although no experimental evidence exists to support a particular function for HLA-G, reasoned speculation about the possible roles of this nonpolymorphic class I molecule is possible. Data derived from sequence analysis, analysis of HLA-G expression patterns, analysis of the extraembryonic expression patterns of other genes, and analysis of decidual lymphocyte phenotype and function provide insight into the possible functions of HLA-G at the maternal/fetal interface and are considered here.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
/
Desenvolvimento Embrionário e Fetal
/
Antígenos HLA
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Crit Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
1993
Tipo de documento:
Article