Multiphasic survival curves for cells of human tumor cell lines: induced repair or hypersensitive subpopulation?
Radiat Res
; 138(1 Suppl): S32-6, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-8146321
ABSTRACT
Survival of the cells of three human tumor cell lines of differing radiosensitivity was measured after irradiation with single doses of X rays (0.05-5 Gy). At doses below 1 Gy, cells were more radiosensitive than predicted by back-extrapolating the high-dose response. This difference was more marked for cells of the radioresistant cell lines than the radiosensitive cell line so that the "true" initial slopes of the survival curves, at very low doses, were similar for the cells of the three cell lines. This phenomenon could reflect an induced radioresistance so that low doses of X rays are more effective per gray than higher doses, because only at higher doses is there sufficient damage to trigger repair systems or other radioprotective mechanisms which can then act during the time course for repair of DNA injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sobrevivência Celular
/
Reparo do DNA
/
Relação Dose-Resposta à Radiação
Limite:
Humans
Idioma:
En
Revista:
Radiat Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido