Melatonin replacement nullifies the effect of light-induced functional pinealectomy on nociceptive rhythm in the rat.
Physiol Behav
; 55(4): 735-9, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-8190803
ABSTRACT
Rats maintained on a 12 h daily photoperiod (1212 LD cycle), exhibited a diurnal variation in sensitivity to both heat-elicited and pressure-elicited pain, with low sensitivity at 2 h before the end of the scotophase and higher at 4 h after the onset of photophase. Functional pinealectomy induced by a single LL day effaced the baseline diurnal rhythm of sensitivity to pressure-elicited pain, and reversed that to heat-elicited pain. Oral administration of physiological doses of melatonin into functionally pinealectomized rats, nullified the effect of functional pinealectomy, restoring the normal baseline rhythms of both pressure-elicited and heat-elicited nociceptive responses. The role of melatonin in modulating nociception is discussed in light of an indoleaminergic-opioid system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Pineal
/
Nociceptores
/
Ritmo Circadiano
/
Luz
/
Melatonina
Limite:
Animals
Idioma:
En
Revista:
Physiol Behav
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Canadá