Expression of 11 beta-OHSD along the nephron of mammals and humans.
Steroids
; 59(2): 100-4, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-8191536
ABSTRACT
The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) plays a major role in the protection of the mineralocorticoid receptor (MR). This cellular mechanism of aldosterone selectivity relies on the coexpression of MR and 11 beta-OHSD in the same cells. Localization of renal 11 beta-OHSD along the nephron is reviewed; comparison of data contained in different species is made; and original data is presented to show that the catalytic activity of the enzyme in tubules from human kidney is the highest in the mineralocorticoid-sensitive distal nephron.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidroxiesteroide Desidrogenases
/
Néfrons
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Steroids
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
França