[Diagnosis using PCR: the direct approach]. / Diagnostic par PCR: l'approche directe.
Schweiz Rundsch Med Prax
; 83(20): 595-8, 1994 May 17.
Article
em Fr
| MEDLINE
| ID: mdl-8209128
ABSTRACT
The direct approach in molecular diagnosis proposes evidences of the mutations underlying the investigated diseases. Due to its speed, specificity and low cost, the Polymerase Chain Reaction (PCR) has become the method of choice in most of these analyses. The direct approach can be either positive or negative. In the first case, the diagnosis is based on the presence of a pathognomonic PCR product, while in the latter, it is the absence of such a product that makes the diagnosis possible. It is evident that both methods have to be validated by several control reactions. Examples out of daily practice illustrate various diagnostic areas.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reação em Cadeia da Polimerase
/
Doenças Genéticas Inatas
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
Fr
Revista:
Schweiz Rundsch Med Prax
Ano de publicação:
1994
Tipo de documento:
Article