Striatal grafts in the ischemic striatum improve pallidal GABA release and passive avoidance.
Brain Res Bull
; 32(5): 517-20, 1993.
Article
em En
| MEDLINE
| ID: mdl-8221145
ABSTRACT
Fetal striatal cells were grafted into the ischemic striatum of rats and pallidal GABA release, and behavioral improvement were investigated. Intraluminal occlusion of the middle cerebral artery (MCA) for 1 h induced ischemic infarcts in the lateral striatum and the adjacent cortex. In ischemic rats, the performance of a passive avoidance task was disturbed, and the pallidal GABA level detected by microdialysis decreased to about a half of control. After the graft, the deficit in the passive avoidance was partially alleviated and the GABA level recovered moderately and increased further by the infusion of an uptake blocker. The data indicate that fetal striatal cell grafts in the ischemic striatum partially restored both chemical and behavioral deficits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem da Esquiva
/
Isquemia Encefálica
/
Corpo Estriado
/
Ácido gama-Aminobutírico
/
Globo Pálido
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão