Long-interval treatment regimen with a desogestrel-containing oral contraceptive.
Contraception
; 48(3): 205-16, 1993 Sep.
Article
em En
| MEDLINE
| ID: mdl-8222651
ABSTRACT
A randomized multicenter study was performed in order to investigate the acceptance of a low-dose OC (30 micrograms of ethinyloestradiol and 150 micrograms of desogestrel), using a 9 weeks on and 1 week off schedule (prolonged regimen, n = 198), compared to a traditional 3 weeks on, 1 week off schedule (standard regimen, n = 96). Haemoglobin and blood pressure remained the same in both groups during the study. No significant differences were found in body weight changes between the two groups. There was significantly more breakthrough bleeding and spotting in the group with prolonged regimen than in the group with standard regimen, but both breakthrough bleeding and spotting decreased during the trial. Irregular bleeding was significantly less in women who were already using OC, compared to "new starters." No serious side effects occurred. Significantly more women stopped the trial because of bleeding problems in the group with prolonged regimen, while there were significantly more women who stopped the trial because of headache in the group with standard regimen. After completing 12 months, or after premature withdrawal from the study, each women completed a questionnaire. Sixty-three per cent of the women preferred the studied alternative and twenty-six per cent preferred the traditional OC.
Palavras-chave
Behavior; Biology; Bleeding; Blood Pressure; Body Weight--changes; Comparative Studies; Contraception; Contraception Termination--indications; Contraceptive Effectiveness; Contraceptive Methods--administraction and dosage; Contraceptive Methods--side effects; Contraceptive Usage; Demographic Factors; Developed Countries; Diseases; Europe; Family Planning; Hemic System; Hemoglobin Level; Menstrual Cycle; Menstruation; Method Acceptability; Metrorrhagia; Northern Europe; Oral Contraceptives, Low-dose--administraction and dosage; Oral Contraceptives, Low-dose--side effects; Oral Contraceptives--administraction and dosage; Oral Contraceptives--side effects; Physiology; Population; Population Dynamics; Reproduction; Research Methodology; Scandinavia; Signs And Symptoms; Smoking; Studies; Sweden; Time Factors; Treatment
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desogestrel
/
Anticoncepcionais Orais Hormonais
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Ano de publicação:
1993
Tipo de documento:
Article