The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected].
J Exp Med
; 178(5): 1837-42, 1993 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-8228830
ABSTRACT
Experimental induction of most autoimmune diseases appears to depend on the activation of CD4+ T helper cells, while CD8+ lymphocytes may have a role in disease progression. To study the role of CD4+ and CD8+ T cell subsets in T cell-dependent autoimmunity, mice lacking CD4 or CD8 molecules after gene targeting were injected with cardiac myosin to induce organ specific autoimmune myocarditis. Mice homozygous for the CD8 mutation (CD8-/-) developed significantly more severe disease as compared to CD4+/-CD8+/- controls. Surprisingly, CD4-/- mice developed autoimmune myocarditis with infiltration of TCR alpha beta +CD4-CD8- T cells in the heart tissue and appearance of autoantibodies. These data demonstrate that the lack of CD4+ or CD8+ T cells has no significant influence on the initiation of autoimmune myocarditis. CD4+ and CD8+ cells regulate disease severity and these results may explain the occurrence of autoimmunity in CD4 immunodeficiencies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Subpopulações de Linfócitos T
/
Antígenos CD8
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Complexo CD3
/
Miocardite
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Canadá