The mechanism of the verapamil-digoxin interaction in renal tubular cells (LLC-PK1).
Life Sci
; 53(24): PL399-403, 1993.
Article
em En
| MEDLINE
| ID: mdl-8246676
ABSTRACT
Verapamil, usually given as a racemic mixture, decreases in vivo and in vitro digoxin renal tubular secretion, which is suggested to be mediated by P-glycoprotein, an ATP-dependent multidrug efflux pump. Importantly, the two enantiomers of verapamil have been reported to similarly inhibit P-glycoprotein-mediated transport of chemotherapeutic agents. In this study, we examined effects of enantiomers of verapamil on digoxin transport across an LLC-PK1 cell monolayer, a model of proximal renal tubular cells. The results indicate that verapamil inhibition of digoxin transport is non-stereospecific. Furthermore, the verapamil-digoxin interaction is not competitive. The two drugs may not share a common initial step in the P-glycoprotein-mediated transport.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Verapamil
/
Digoxina
/
Túbulos Renais
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Canadá