Metabolism of triacetin-derived acetate in dogs.
Am J Clin Nutr
; 58(6): 908-11, 1993 Dec.
Article
em En
| MEDLINE
| ID: mdl-8249877
ABSTRACT
Triacetin is a water-soluble triglyceride that may have a role as a parenteral nutrient. In the present study triacetin was administered intravenously to mongrel dogs (n = 10) 2 wk after surgical placement of blood-sampling catheters in the aorta and in the portal, hepatic, renal, and femoral veins. [1-14C]Acetate was infused to allow quantification of organ uptake of acetate as well as systemic turnover and oxidation. Systemic acetate turnover accounted for approximately 70% of triacetin-derived acetate, assuming complete hydrolysis of the triglyceride. Approximately 80% of systemic acetate uptake was rapidly oxidized. Significant acetate uptake was demonstrated in all tissues (liver, 559 +/- 68; intestine, 342 +/- 23; hindlimb, 89 +/- 7; and kidney, 330 +/- 37 mumol/min). In conclusion, during intravenous administration in dogs, the majority of infused triacetin undergoes intravascular hydrolysis, and the majority of the resulting acetate is oxidized. Thus, energy in the form of short-chain fatty acids can be delivered to a resting gut via intravenous infusion of a short-chain triglyceride.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triacetina
/
Acetatos
Limite:
Animals
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Mongólia