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Hemodynamic effects of the administration of tumor-infiltrating lymphocytes to cancer patients.
Marincola, F M; Balkissoon, J; Schwartzentruber, D J; Hom, S S; Concepcion, R; Marcus, S G; Yannelli, J; Topalian, S L; Parkinson, D R; Rosenberg, S A.
Afiliação
  • Marincola FM; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
J Immunother Emphasis Tumor Immunol ; 13(4): 282-8, 1993 May 04.
Article em En | MEDLINE | ID: mdl-8334112
Tumor-infiltrating lymphocytes (TILs) can mediate tumor regression in selected patients with advanced cancer. To study some of the physiological changes associated with TIL administration, hemodynamic effects were measured while 2 x 10(10) to 20 x 10(10) TILs (mean 10 +/- 1 x 10(10)) were infused into 22 patients. In 10 patients, the first bag of TILs was administered without any interleukin-2 (IL-2) in the infusion bag; subsequent bags in the same patients and all bags in the next 12 patients contained IL-2 in low concentrations (300,000 IU). Two hours following infusion (as compared with baseline), patients developed tachycardia (110 +/- 3.3 vs. 76 +/- 3.5 beats/min; p < 0.001), increased cardiac index (4.9 +/- 0.2 vs. 3.2 +/- 0.13 L/min/m2; p < 0.001), decreased systemic vascular resistance (677 +/- 37 vs. 1185 +/- 63 dyn/s/cm5; p < 0.001), and increased pulmonary artery diastolic pressure (15.9 +/- 1.4 vs. 10.6 +/- 1.1 mm Hg; p = 0.002). No significant changes in systemic blood pressure were noted. Analysis of data obtained in the 10 patients after infusion of the first bag of TILs (4.5 +/- 0.4 x 10(10)) without IL-2 present in the infusate revealed similar, though less severe, changes. No significant correlation was noted between in vitro production of tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor by TILs and hemodynamic effects when administered to patients. These results indicate that TIL infusion can cause hemodynamic changes similar to those previously reported in patients undergoing IL-2 therapy.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoterapia Adotiva / Linfócitos do Interstício Tumoral / Hemodinâmica / Neoplasias Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Immunother Emphasis Tumor Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / NEOPLASIAS Ano de publicação: 1993 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoterapia Adotiva / Linfócitos do Interstício Tumoral / Hemodinâmica / Neoplasias Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Immunother Emphasis Tumor Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / NEOPLASIAS Ano de publicação: 1993 Tipo de documento: Article