Progressive nemaline rod myopathy in a woman coinfected with HIV-1 and HTLV-2.
Mt Sinai J Med
; 60(3): 242-6, 1993 May.
Article
em En
| MEDLINE
| ID: mdl-8345853
ABSTRACT
Nemaline-rod myopathy was recently reported in eight young males infected with human immune deficiency virus type 1 (HIV-1). A 41-year-old woman had a 2-year history of progressive proximal-muscle weakness. Muscle biopsy demonstrated the presence of nemaline rods, predominantly in type 1 fibers. She was coinfected with HIV-1 and HTLV-2, as evidenced by positive polymerase chain reaction and serology. There was no lymphopenia or CD4 lymphopenia, despite an abnormal T-cell subset ratio, high CD8 count, skin anergy, and depressed in vitro response to mitogens. This case raises the possibility that dual infection may play a role in the pathogenesis of the rare nemaline-rod myopathies of HIV-infected patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HTLV-II
/
Infecções por HIV
/
HIV-1
/
Doenças Musculares
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Mt Sinai J Med
Ano de publicação:
1993
Tipo de documento:
Article