Oxidised low density lipoproteins induce iron release from activated myoglobin.
FEBS Lett
; 326(1-3): 177-82, 1993 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-8391992
ABSTRACT
Recent reports have detected the presence of iron in human atherosclerotic lesions [Biochem. J. 286 (1992) 901-905]. This study provides evidence for a biochemical mechanism whereby iron is released from myoglobin by low density lipoprotein (LDL) which has become oxidised by the ferryl myoglobin species. The haem destabilisation and iron release are inhibited by monohydroxamate compounds and desferrioxamine through their ability to inhibit the propagation of LDL oxidation. Thus, iron may derive from the myoglobin released from ruptured cells in the oxidising environment of the atherosclerotic lesion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ferro
/
Lipoproteínas LDL
/
Mioglobina
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido