In vitro and in vivo efficacy of a new connector device for continuous ambulatory peritoneal dialysis.
Perit Dial Int
; 13 Suppl 2: S148-51, 1993.
Article
em En
| MEDLINE
| ID: mdl-8399552
ABSTRACT
The purpose of this study was to evaluate the in vitro and in vivo efficacy of a new connection system for continuous ambulatory peritoneal dialysis (CAPD), called the T-set. With this system the patient wears a 27-cm extension line filled with Amuchina during the dwell time; the bag is made of a fill container linked to a drainage tube with a Y-shaped set. For bag exchange, only one connection is needed and this is subsequently flushed with the entire drainage volume. The in vitro efficacy of the system was tested with 20 sets filled with 10 mL of Amuchina and inoculated in the distal lumen with 2.1 x 10(3) colony-forming units (cfu) of S. aureus. After an incubation of 4-6 hours at 35-37 degrees C, three dialysate samples per set were collected, respectively, at the beginning of drainage and filling. All 120 samples were negative, whereas two control sets, filled with a phosphate-buffered saline, had positive drainage samples, and at least one positive infusion sample, indicating the efficacy of Amuchina in sterilizing the system under conditions simulating touch contamination. To evaluate the in vivo efficacy, safety, and acceptability of the T-system, a prospective randomized controlled trial was performed in seven centers a control group (CG) of 56 patients (follow-up 952.3 months, mean +/- SD 17.0 +/- 7.8) was treated with a long branch (21 patients) or short branch (35 patients) Y-set and a test group (TG) of 66 patients (follow-up898.1 months, mean +/- SD 13.6 +/- 7.8) with the T-set.(ABSTRACT TRUNCATED AT 250 WORDS)
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diálise Peritoneal Ambulatorial Contínua
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Observational_studies
Limite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Perit Dial Int
Assunto da revista:
NEFROLOGIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Itália