Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy.
Science
; 260(5105): 235-8, 1993 Apr 09.
Article
em En
| MEDLINE
| ID: mdl-8469976
ABSTRACT
The myotonic dystrophy mutation has recently been identified; however, the molecular mechanism of the disease is still unknown. The sequence of the myotonin-protein kinase gene was determined, and messenger RNA spliced forms were identified in various tissues. Antisera were developed for analytical studies. Quantitative reverse transcription-polymerase chain reaction and radioimmunoassay were used to demonstrate that decreased levels of the messenger RNA and protein expression are associated with the adult form of myotonic dystrophy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
RNA Mensageiro
/
Proteínas Serina-Treonina Quinases
/
Músculos
/
Distrofia Miotônica
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1993
Tipo de documento:
Article