Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.
Science
; 260(5107): 544-6, 1993 Apr 23.
Article
em En
| MEDLINE
| ID: mdl-8475387
ABSTRACT
Surface expression of the CD45 tyrosine phosphatase is essential for the T cell antigen receptor (TCR) to couple optimally with its second messenger pathways. CD45 may be required to dephosphorylate a TCR-activated protein tyrosine kinase, which then transduces an activation signal from the TCR. A chimeric molecule that contained extracellular and transmembrane sequences from an allele of a major histocompatibility class I molecule and cytoplasmic sequences of CD45 restored TCR signaling in a CD45-deficient mutant T cell line. Thus, expression of the complex extracellular domain of CD45 is not required for the TCR to couple to its signaling machinery.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Transdução de Sinais
/
Antígenos Comuns de Leucócito
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1993
Tipo de documento:
Article