Conditions of validation and use of the screening method for vaccine efficacy evaluation.
Rev Epidemiol Sante Publique
; 41(2): 155-60, 1993.
Article
em En
| MEDLINE
| ID: mdl-8493394
ABSTRACT
If PV is the proportion of the target population vaccinated and PCV the proportion of cases in the same population who have been previously vaccinated, vaccine efficacy can be computed as (PV-PCV)/[PV(1-PCV)]. In the screening method, this formula is currently applied to sample values. The objective of this paper is to provide the corresponding statistical tools. Taylor series expansion has been used to derive the bias, variance and confidence interval of the estimate. The bias may be very high when vaccine efficacies are low. It is below 1% for vaccine efficacies higher than 80%. Monte Carlo simulations were used to assess the departure from normality of the estimate. The number of subjects required by the method for given precisions are presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas
/
Interpretação Estatística de Dados
Tipo de estudo:
Diagnostic_studies
/
Health_economic_evaluation
/
Prognostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
En
Revista:
Rev Epidemiol Sante Publique
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
França