Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.
Endocrinology
; 132(6): 2484-90, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-8504751
ABSTRACT
We report that human myometrium contains G alpha i1, G alpha i3, and G alpha q, and G alpha 11, which are expressed at similar levels in tissues from pregnant and nonpregnant women. G alpha i2 is also expressed, but at a slightly reduced level, in tissue taken from pregnant compared to nonpregnant donors. The major finding of this investigation is the substantial increase in G alpha s expression in pregnant myometrium. The increase in G alpha s levels may play a crucial role in maintaining relaxation of the uterus by favoring cAMP formation during pregnancy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravidez
/
Proteínas de Ligação ao GTP
/
Miométrio
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido