A presynaptic inositol-5-phosphatase.
Nature
; 379(6563): 353-7, 1996 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-8552192
ABSTRACT
Synaptojanin is a nerve terminal protein of relative molecular mass 145,000 which appears to participate with dynamin in synaptic vesicle recycling. The central region of synaptojanin defines it as a member of the inositol-5-phosphatase family, which includes the product of the gene that is defective in the oculocerebrorenal syndrome of Lowe. Synaptojanin has 5-phosphatase activity and its amino-terminal domain is homologous with the yeast protein Sac1 (Rsd1), which is genetically implicated in phospholipid metabolism and in the function of the actin cytoskeleton. The carboxy terminus, which is of different lengths in adult and developing neurons owing to the alternative use of two termination sites, is proline-rich, consistent with the reported interaction of synaptojanin with the SH3 domains of Grb2 (refs 1, 2). Synaptojanin is the only other major brain protein besides dynamin that binds the SH3 domain of amphiphysin, a presynaptic protein with a putative function in endocytosis. Our results suggest a link between phosphoinositide metabolism and synaptic vesicle recycling.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terminações Pré-Sinápticas
/
Monoéster Fosfórico Hidrolases
/
Proteínas do Tecido Nervoso
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos