Oral cyclosporin A restores hair growth in the DEBR rat model for alopecia areata.
Clin Exp Dermatol
; 20(2): 127-31, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-8565246
ABSTRACT
The Dundee experimental bald rat (DEBR) undergoes hair loss associated with the development of peri- and intrafollicular mononuclear cell infiltrates, as occurs in human alopecia areata. We studied the effect of orally administered cyclosporin A (10 mg/kg; 5 days/week for 7 weeks) on established lesional DEBR rats displaying extensive areas of hair loss. New hairs appeared after 10 days and there was simultaneous regrowth of hair over the whole body with restoration of a full pelt by 5 weeks. Semiquantitative histological examination of flank skin biopsies revealed early reduction of the cellular infiltrate associated with conversion of dystrophic anagen follicles to normal, hair-producing follicles. These results confirm the value of the DEBR model of alopecia areata in evaluating existing and new therapies for this disease in humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclosporina
/
Alopecia em Áreas
/
Cabelo
/
Imunossupressores
Limite:
Animals
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Reino Unido