Regulation of C/EBP beta/NF-M activity by kinase oncogenes.
Curr Top Microbiol Immunol
; 211: 129-36, 1996.
Article
em En
| MEDLINE
| ID: mdl-8585943
ABSTRACT
CAAT Enhancer Binding proteins (C/EBP) belong to a family of transcription factors which are implicated in a number of developmental and growth regulatory processes. One member of this family known as C/EBP beta (called NF-M in the chicken system) is particularly important in myelomonocytic cells because it is targeted by kinases and collaborates with the Myb oncoprotein to induce the expression of myeloid specific genes. Experiments dissecting the structure of NF-M suggest that it is a repressed transcription factor. Using the yeast two-hybrid system we showed that a negative regulatory domain masks the transactivation domain. Examination of NF-M mutants suggests that kinase (proto-) oncogenes uncover the concealed transcriptional activity by phosphorylation of the negative regulatory domain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Nucleares
/
Proteínas Oncogênicas
/
Proteínas Quinases Dependentes de Cálcio-Calmodulina
/
Proteínas de Ligação a DNA
Idioma:
En
Revista:
Curr Top Microbiol Immunol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Alemanha