The time-course of micronucleated polychromatic erythrocytes in mouse bone marrow and peripheral blood.
Mutat Res
; 350(2): 349-58, 1996 Mar 09.
Article
em En
| MEDLINE
| ID: mdl-8600364
ABSTRACT
The time-course of micronucleated polychromatic erythrocytes (MPCE) in mouse bone marrow and peripheral blood, induced by an acute 0.1 Gy dose of X-rays, was determined using flow cytometric analysis, which made frequent sampling possible and allowed use of a dose low enough not to affect erythroid cell proliferation. The frequency of MPCE (fMPCE) began to increase in the bone marrow at 10 h after irradiation and reached a maximum at 28 h after irradiation. In the peripheral blood fMPCE began to increase at 20 h after irradiation and peaked at about 40 h after irradiation. The time-course found is discussed on the basis of data on the differentiation of erythroid cells. The results indicate that the micronuclei registered in polychromatic erythrocytes may originate from lesions induced not only during the last cell cycle but also during earlier ones. After an acute dose of 1.0 Gy of X-rays the maximum fMPCE was delayed both in bone marrow and peripheral blood reflecting an effect on the cell cycle progression of erythroblasts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Micronúcleos com Defeito Cromossômico
/
Eritrócitos
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Suécia