[Effect of doxycycline in the treatment of progressive periodontal disease]. / Efekti doksiciklina u lecenju uznapredovale parodontopatije.

The aim of this paper was to establish effects of doxycycline on gingival inflammation and depth of periodontal sacculi in individuals with a form of paradontopathy in progress. The investigation was performed in two parallel groups of examinees from 38 to 56 years of age. The same kind of parodontal therapy was carried out in all patients and after that by a method of random sampling, where the examiner has not taken part, 30 patients were chosen and doxycycline was applied per os (200 mg on the first day and then 100 mg a day during a period of 13 days). Analyzing gathered results a significant decrease of gingival inflammation and of periodontal sacculi was established in persons treated with doxycycline. These results show that a 2 week application of doxycycline per os in combination with parodontal therapy is effective in treating paradontopathy in progress.