Cimetidine does not alter sparfloxacin pharmacokinetics.
Int J Clin Pharmacol Ther
; 33(11): 585-7, 1995 Nov.
Article
em En
| MEDLINE
| ID: mdl-8688981
ABSTRACT
The interaction between cimetidine and sparfloxacin was studied in 10 healthy volunteers who received a single oral dose of 400 mg sparfloxacin on the third day of an 8 day cimetidine (400 mg t.i.d.) or placebo randomly assigned treatment. No statistically significant differences were observed in the pharmacokinetic parameters (Cmax-AUC-T1/2-urinary excretion and metabolic ratio) of sparfloxacin following the 2 treatment. Cimetidine does not affect absorption, metabolism or urinary excretion of sparfloxacin; consequently, patients exposed to this drug combination are not at risk.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cimetidina
/
Quinolonas
/
Fluoroquinolonas
/
Antagonistas dos Receptores H2 da Histamina
/
Anti-Infecciosos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Int J Clin Pharmacol Ther
Assunto da revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
França