Do human lymphocytes exposed to the fallout of the Chernobyl accident exhibit an adaptive response? III. Challenge with bleomycin in lymphocytes from children hit by the initial acute dose of ionizing radiation.
Mutat Res
; 354(1): 77-80, 1996 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-8692209
ABSTRACT
In the present paper, we report data on the possible adaptive response, induced in vivo by exposure to ionizing radiation to a challenge treatment with the radiomimetic glycopeptide bleomycin (BLM). Lymphocytes from children living in Pripjat at the time of the Chernobyl accident, and thus hit by the initial acute dose of ionizing radiation, were treated for the last 5 h of culture with 0.004 U/ml BLM. Significantly lower chromosome damage was found only in lymphocytes from children who, independently of the initial acute exposure to ionizing radiation, still showed a 137Cs internal contamination, due to persistent continuous exposure to low doses of radiation. The present results indicate that past exposure to acute high dose of ionizing radiation does not interfere with resistance to BLM which is related to internal contamination.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Centrais Elétricas
/
Bleomicina
/
Adaptação Fisiológica
/
Linfócitos
/
Aberrações Cromossômicas
/
Liberação Nociva de Radioativos
/
Antibacterianos
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália