The value of CSF analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis.
Arq Neuropsiquiatr
; 53(4): 760-5, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8729769
ABSTRACT
Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paraparesia Espástica Tropical
/
Epilepsia
/
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Arq Neuropsiquiatr
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Alemanha