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Molecules with neurotrophic effects on the human developing mesencephalic dopaminergic neurons.
Silani, V; Bernasconi, S; Pizzuti, A; Sampietro, A; Brioschi, A; Buscaglia, M; Scarlato, G.
Afiliação
  • Silani V; Institute of Neurology, University of Milan Medical School, Italy.
J Neural Transm Suppl ; 45: 287-96, 1995.
Article em En | MEDLINE | ID: mdl-8748637
ABSTRACT
Parkinson's disease (PD) is characterized by the degeneration of the mesencephalic dopaminergic (mesDA) neurons innervating the striatum. Neurotrophic factor(s) that prevents the degeneration and increases the functional activity of the remaining mesDA neurons are of substantial clinical interest. The origin and development of mesDA neurons were characterized in the human mesencephalon from 5.0 to 12 Postconception (PC) weeks. Tyrosine Hydroxylase (TH) immunoreactive cells were first demonstrated at 5.5 PC weeks next to the ventricular zone. In primary culture, TH immunoreactive neurons represent 3 to 5% of the total cells at days 7 in vitro and basic Fibroblast growth factor (bFGF) was demonstrated to induce a significant increase of both TH immunoreactive cell number and TH enzymatic activity. This effect was mediated by proliferating glial fibrillary acidic protein immunoreactive cells. Nerve growth factor treatment did not have any appreciable effect. The effect of bFGF on TH positive cells described in this human bioassay is only a preliminary evidence that, if confirmed by experiments in vivo, may provide a starting rationale for investigating alternative strategies in the treatment of PD.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substância Negra / Dopamina / Fator 2 de Crescimento de Fibroblastos / Fatores de Crescimento Neural / Neurônios Limite: Humans Idioma: En Revista: J Neural Transm Suppl Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Itália
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substância Negra / Dopamina / Fator 2 de Crescimento de Fibroblastos / Fatores de Crescimento Neural / Neurônios Limite: Humans Idioma: En Revista: J Neural Transm Suppl Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Itália