Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer.
Nat Med
; 2(9): 985-91, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8782455
ABSTRACT
A retroviral vector containing the wild-type p53 gene under control of a beta-actin promoter was produced to mediate transfer of wild-type p53 into human non-small cell lung cancers by direct injection. Nine patients whose conventional treatments failed were entered into the study. No clinically significant vector-related toxic effects were noted up to five months after treatment. In situ hybridization and DNA polymerase chain reaction showed vector-p53 sequences in posttreatment biopsies. Apoptosis (programmed cell death) was more frequent in posttreatment biopsies than in pretreatment biopsies. Tumor regression was noted in three patients, and tumor growth stabilized in three other patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retroviridae
/
Terapia Genética
/
Genes p53
/
Técnicas de Transferência de Genes
/
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
Limite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos