The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.
Cell
; 86(6): 973-83, 1996 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-8808632
ABSTRACT
The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB). Here we demonstrate that these parallels extend to the immune response of Drosophila. In particular, the intracellular components of the dorsoventral signaling pathway (except for dorsal) and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults. We also show that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection. Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genes MHC da Classe II
/
Genes de Insetos
/
Receptores de Superfície Celular
/
Proteínas de Insetos
/
Proteínas de Drosophila
/
Drosophila
Limite:
Animals
Idioma:
En
Revista:
Cell
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França