[The immunochemical and biological properties of monoclonal antibodies to Chlamydia trachomatis]. / Immunokhimicheskie i biologicheskie svoistva monoklonal'nykh antitel k Chlamydia trachomatis.
Zh Mikrobiol Epidemiol Immunobiol
; (1): 3-6, 1996.
Article
em Ru
| MEDLINE
| ID: mdl-8820666
ABSTRACT
In this work some properties of 11 monoclonal antibodies to C.trachomatis, obtained in our earlier investigations, were studied and the antigens recognized by these McAb were characterized. Some McAb reacted with a genus-specific thermostable antigen, sensitive to sodium metaperiiodate and having a mol. wt. of 10 - 12 kD. Other McAb interacted with C.trachomatis species- and subspecies-specific thermostable proteins with a mol. wt. of 40 kD. Two McAb reacted with thermolabile protein with a mol. wt. of 32 kD and some C.trachomatis unidentified protein. The in vitro study of two McAb, active against subspecies-specific proteins, revealed the neutralizing activity of these McAb. Thus McAb obtained in this investigation may be for the differential identification of different determinants and for further analysis of the antigenic structure of C.trachomatis, as well as for the development of modern immunodiagnostic preparations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chlamydia trachomatis
/
Anticorpos Antibacterianos
/
Anticorpos Monoclonais
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Federação Russa