Evaluation of an epoxy-fixed biological patch with ionically bound heparin as a pericardial substitute.
Biomaterials
; 17(17): 1693-701, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8866031
ABSTRACT
In an attempt to develop an improved pericardial substitute, we undertook the development of an epoxy-fixed biological patch with ionically bound heparin. The study was to evaluate the cross-linking characteristics of this newly developed biological patch using its glutaraldehyde-fixed counterpart as a control. In addition, the feasibility of using this newly developed biological patch as a pericardial substitute was assessed in a canine model. In the study, it was observed that the epoxy-fixed biological patch appeared more similar to the native pericardium in colour and was more pliable than its glutaraldehyde-fixed counterpart. Also, both the epoxy- and glutaraldehyde-fixed biological patches had significant increases in fixation index and denaturation temperature as compared to the fresh one (p < 0.05). In the canine study, the epoxy-fixed biological patch with ionically bound heparin was found to have significantly less adhesion formation than those currently used clinically (p < 0.05).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pericárdio
/
Transplante Heterólogo
/
Materiais Biocompatíveis
/
Heparina
/
Compostos de Epóxi
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biomaterials
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Taiwan