Characteristics of shed snake skin permeability to indomethacin and fatty alcohols.
J Pharm Pharmacol
; 48(7): 680-4, 1996 Jul.
Article
em En
| MEDLINE
| ID: mdl-8866328
ABSTRACT
To investigate the utilities of a shed snake skin as a model membrane for preclinical studies of transdermal drug delivery, the flux of indomethacin was determined under various conditions by using a diffusion cell. The flux of fatty alcohols was determined and compared with that in human skin reported in references. The esterase activity of shed snake skin was also determined. It was found that the flux of indomethacin decreased with an increase of pH and the amount of ethanol in a vehicle. The flux of indomethacin increased by the addition of Azone, N-methyl-2-pyrrolidone and N,N-dimethyl-m-toluamide in the cream. The flux of fatty alcohols in shed snake skin was greater than that reported in human skin, and shed snake skin had similar esterase activity to human skin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Anti-Inflamatórios não Esteroides
/
Indometacina
/
Avaliação Pré-Clínica de Medicamentos
/
Álcoois Graxos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão