The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle.
Br J Pharmacol
; 119(2): 185-6, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8886394
ABSTRACT
We present entirely novel evidence that DL-threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. We conclude that DL-threo dihydrosphingosine may represent an important pharmacological cell-permeable agent that may be usefully employed to block smooth muscle cell proliferation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esfingosina
/
Traqueia
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Transdução de Sinais
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Proteínas Quinases Dependentes de Cálcio-Calmodulina
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Proteínas Quinases Ativadas por Mitógeno
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Inibidores Enzimáticos
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Músculo Liso
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1996
Tipo de documento:
Article