The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor.
Br J Pharmacol
; 119(4): 619-21, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8904633
ABSTRACT
In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Capilares
/
Endotélio Vascular
/
Divisão Celular
/
Movimento Celular
/
Fatores de Crescimento Endotelial
/
Hidroxiquinolinas
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália