Membrane glycoprotein changes in primary mammary tumors associated with autonomous growth.
Cancer Lett
; 3(3-4): 133-8, 1977 Sep.
Article
em En
| MEDLINE
| ID: mdl-902251
ABSTRACT
Primary and transplanted mammary tumors of the GR mouse were explanted in tissue culture and grown in the presence of radioactive fucose. Labelled membrane glycopeptides were isolated and compared by cochromatography with differentially labelled glycopeptides from normal mammary gland tissue. Differences with controls in the glycopeptide elution profiles were observed in autonomous, hormone-independent tumors but were absent in histologically similar tumors which required a continuous hormonal stimulus for growth. The results suggest that alterations in membrane glycopeptides are associated with the capacity of autonomous, hormone-independent growth of murine adenocarcinoma cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas
/
Neoplasias Mamárias Experimentais
/
Proteínas de Neoplasias
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1977
Tipo de documento:
Article