Differential diagnosis of pleural effusion by lactate dehydrogenase isoenzyme analysis.
Chest
; 111(3): 648-51, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9118702
ABSTRACT
STUDY OBJECTIVE:
To determine the diagnostic value of pleural fluid lactate dehydrogenase (LDH) isoenzyme analysis in the differential diagnosis of pleural fluid. PATIENTS ANDMETHODS:
Eighty-seven consecutive patients with pleural effusion caused by congestive heart failure (33), infection (33), and malignancy (21) comprised a derivation set of patients. Pleural fluid LDH activity and isoenzyme pattern were established in all patients and analyzed by the classification and regression trees (CART) method. An additional group of 20 consecutive patients comprised a validation set that was used for cross-validation of CART-derived decision tree.RESULTS:
A decision tree, with a positive predictive value of 83%, was constructed and validated by data from a validation set of patients.CONCLUSIONS:
Pleural fluid LDH isoenzyme pattern may be helpful for the differential diagnosis of the most common causes of pleural effusions congestive heart failure, infections, and malignancy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Derrame Pleural
/
Ensaios Enzimáticos Clínicos
/
L-Lactato Desidrogenase
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Chest
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Israel