The beta-core fragment of human chorionic gonadotropin: biochemical background and clinical application.
Anticancer Res
; 17(2B): 1255-72, 1997.
Article
em En
| MEDLINE
| ID: mdl-9137483
ABSTRACT
In this review an overview is given of the possible applications and usefulness of the beta-core fragment of hCG (beta cf-hCG) as an urinary tumor marker. Expression of human Chorionic Gonadotropin (hCG) is an important indicator of malignant transformation. The biochemical background of this glycoprotein hormone and the degradation pathway towards beta cf-hCG is described. There are two main pathways peripheral degradation in the serum and the renal parenchymal degradation. HCG and its subunits show immunoreactivity and cross-reactivity with other glycoprotein hormones and their subunits. The different "in house" methods to determine beta cf-hCG developed and used by various research institutes are described. In various types of cancer, concentrations of hCG as well as its beta-subunit may be elevated, allowing the clinical use of these substances as a tumor marker. The relation between laboratory outcome and clinical status is assessed, with emphasis on the beta cf-hCG in gynecological malignancies. The limitations of the use of beta cf-hCG as a tumor marker are discussed. The stability of beta cf-hCG may allow distant follow-up in samples sent to the laboratory by mail.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Gonadotropina Coriônica Humana Subunidade beta
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Holanda