Activation of the G protein Gq/11 through tyrosine phosphorylation of the alpha subunit.
Science
; 276(5320): 1878-81, 1997 Jun 20.
Article
em En
| MEDLINE
| ID: mdl-9188537
ABSTRACT
Various receptors coupled to the heterotrimeric guanine nucleotide-binding protein Gq/11 stimulate formation of inositol-1,4,5-trisphosphate (IP3). Activation of these receptors also induces protein tyrosine phosphorylation. Formation of IP3 in response to stimulated receptors that couple to Gq/11 was blocked by protein tyrosine kinase inhibitors. These inhibitors appeared to act before activation of Gq/11. Moreover, stimulation of receptors coupled to Gq/11 induced phosphorylation on a tyrosine residue (Tyr356) of the Galphaq/11 subunit, and this tyrosine phosphorylation event was essential for Gq/11 activation. Tyrosine phosphorylation of Galphaq/11 induced changes in its interaction with receptors. Therefore, tyrosine phosphorylation of Galphaq/11 appears to regulate the activation of Gq/11 protein.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Colinérgicos
/
Receptores de Glutamato Metabotrópico
/
Fosfotirosina
/
Proteínas de Ligação ao GTP
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão