Buspirone, a 5-hydroxytryptamine1A agonist, is active in cerebellar ataxia. Results of a double-blind drug placebo study in patients with cerebellar cortical atrophy.
Arch Neurol
; 54(6): 749-52, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9193210
ABSTRACT
OBJECTIVE:
To establish the antiataxic effect of buspirone hydrochloride, a serotonergic 5-hydroxytryptamine1A (5-HT1A) agonist, in a homogenous group of patients characterized by the same well-defined single condition, cerebellar cortical atrophy.SETTING:
University ataxia research center.METHODS:
Double-blind randomized study of buspirone vs placebo during a 4-month period. PATIENTS Nineteen patients met the inclusion criteria; all completed the study. Of these 19 patients, 9 were treated with placebo and 10 were treated with the drug. MAIN OUTCOMEMEASURES:
A semiquantitative scale for kinetic and static ("postural") cerebellar functions; quantitative clinical measurements measuring time in standard tests that evaluated stance, speech, writing, and drawing; and posturographic analysis of the sway path and sway area of the center-of-foot pressure. The primary end point was improvement of the posttherapeutic change of one of the semiquantitative ataxic scores. The secondary end points were modification of the changes of quantitative measures--clinical or posturographic.RESULTS:
In intention-to-treat analysis, a significant improvement of the primary end point, ie, the posttherapeutic change of the ataxic kinetic score, was shown. Among secondary end points, the maximum time of standing with feet together also was significantly improved.CONCLUSIONS:
Buspirone is active in cerebellar ataxia of patients with cerebellar atrophy. These results confirm the data suggested by open-label studies with buspirone. However, the effect is partial and not clinically major. These pharmacological results might be due to serotonergic mechanisms and confirm a possible link between cerebellar ataxia and the metabolism of serotonin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Buspirona
/
Ataxia Cerebelar
/
Cerebelo
/
Agonistas do Receptor de Serotonina
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Arch Neurol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França